Upper Keys Humane Society

We rescue & rehome animals in the Upper Keys.


The Upper Keys Humane Society has been rescuing dogs and cats in Key Largo and the Upper Keys area since 1973. We take great pride in matching families in search for a “furever friend” to the right animal, and in the fact that we are a NO-KILL society/shelter.

Can’t imagine my life without Dexter and Doakes (first named Binks and Tomas) and I have Karla to thank for that. She knows the animals like her own and helped make the match.


Animals Rehomed This Year


Animals Rehomed since 1973

We couldn’t ask for a better dog. Captain brings so much laughter and love to our everyday life. Thank you for this amazing gift.






Animal Care


Shelter Operations


Rescue & Emergency


Administration Costs

Every Donation Counts

We are the only non-profit, no-kill Humane Society in Key Largo and the Upper Keys. For this reason, we rely on the continued support of our community. Contributions are our only source of income and are tax deductible. The shelter and our animals greatly appreciate your help as a donor, volunteer and/or supporter!


Donation Information

I would like to make a donation in the amount of:

$1,000 $500 $100 $50 $10


I would like this donation to automatically repeat each month

Tribute Gift

Check here to donate in honor or memory of someone

Check here if this is a memorial gift

Send acknowledgement via email to

Send acknowledgement via postal mail to

Donor Information

Please do not publish my name. I would like to remain anonymous.

Donor Address

I am a UK taxpayer and my gift qualifies for Gift Aid.

More Ways to Support Us


If you have some extra time on your hands, we are always looking for help in the following areas:

  • Animal Enrichment
  • Animal Grooming
  • Administration Help
  • Shelter Operations
  • Animal Transport
  • Upcoming Events & Fundraising

If you are interested in volunteering, let us know what you’d like to help with. Someone will be in touch with you shortly with further details.


Foster homes play a huge role for animals who made need a little extra time and care before adoption, and they open up another spot in our shelter for another animal who needs it.

We provide:

  • Food
  • Animal Supplies
  • Medical Care
  • Support during Fostering

If you’re interested, let us know and someone will be in touch with you soon!

Wish List

  • Aluminum Cans
  • Newspapers
  • Cleaning products
  • Bleach
  • Dish Soap
  • Hand sanitizer
  • Towels
  • Cat Litter
  • Cat food (wet/dry)
  • Dog food (wet/dry)
  • Treats
  • Toys


101617 Overseas Highway Key Largo, FL 33037

Mailing Address

P.O. Box 370511
Key Largo, FL 33037

Phone + Hours

(305) 451-3848
Monday – Friday, 9 AM – 4 PM

Email Us

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